To learn more about the biology underlying gene expression changes, we can use a gene list to perform pathway or gene ontology (GO) enrichment analysis. 

• Select the Feature list data node
• Select Biological interpretation from the task menu 
• Select Enrichment analysis to perform GO enrichment analysis (Figure 1)
  
  

Figure 1. Invoking Enrichment analysis

• Select GO from the Gene set drop-down menu
• Select Finish 

An Enrichment task node will be generated (Figure 2).

Figure 2. Enrichment task node

•  Double-click the Enrichment task node to open the task report (Figure 3)
  
  

Figure 3. Viewing the Enrichment task report

The Enrichment task report spreadsheet lists GO terms by ascending p-value with the most significant GO term at the top of the list. Also included are the enrichment score, the number of genes from that GO term in the list, and the number of genes from that GO term that are not in the list. 

To view the genes associated with each GO term, select  to open the extra details page.  

For more information about GO enrichment analysis, please see the Gene Ontology Enrichment user guide. 

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