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SubtitleText Hierarchical Clustering of Down_Syndrome_vs_Normal (A) AnchorName Hierarchical Clustering

The graph (Figure 2) illustrates the standardized gene expression level of each gene in each sample. Each gene is represented in one column, and each sample is represented in one row. Genes which are unchanged are with no difference in expression have a value of zero and are colored black. Genes with increased expression in Down syndrome samples have positive values and are colored red. Genes with reduced expression in Down syndrome samples have negative values and are colored green. Down syndrome samples are colored red and normal samples are colored orange. On the left-hand side of the graph, we can see that the Down syndrome samples cluster together.

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SubtitleText Adding Chromosomal Location annotation AnchorName Add Rows/Columns to Spreadsheet

Interestingly, of the 23 genes of the Down_Syndrome_vs_Normal (A) spreadsheet, 20 genes are located on chromosome 21. This suggests that the gene expression changes associated with Down syndrome observed in this study are primarily located on chromosome 21, not distributed throughout the genome, an important finding of this study. 

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