A fusion gene is a hybrid gene that combines parts of two or more original genes. They can form as a result of chromosomal rearrangements (such as translocation, interstitial deletion, or chromosomal inversion) or abnormal transcription and have been shown to act as drivers of malignant transformation or/and progression in various neoplasms (1). The discovery and characterization of fusion genes hav been greatly facilitated by the use of NGS (2) and several computational algorithms have been developed to detect them. 

This chapter covers will illustrate how to detect fusion genes by: 

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