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• Constant values: specify a value to replace the missing data
• Maximum: use maximum value of samples/cells or features to replace missing data depends transform option
• Mean: use mean value of samples/cells or features to replace missing data depends transform option
• Median: use median value of samples/cells or features to replace missing data depends transform option
• Minimum: use minimum value of samples/cells or features to replace missing data depends transform option
• K-nearest neighbor (mean): specify number of neighbors (N), Euclidean metric is used to compute neighbors, use mean of (N) neighbors to replace missing data
• K-nearest neighbor (median): specify number of neighbors (N), Euclidean metric is used to compute neighbors, use median of (N) neighbors to replace missing data

References

1. Dana Pe'er. MAGIC: A diffusion-based imputation method reveals gene-gene interactions in single-cell RNA-sequencing data