...

Using multimodel inference appears to be a better alternative to the ad hoc method in DESeq2 that switches shrinkage on and off all the way. Once again, it is both technically possible and emotionally tempting to automate the handling of abnormal features by enabling both Lognormal models in GSA and applying them to all of the transcripts. Unfortunately, that can make the results less reproducible overall, even though it is likely to yield more accurate conclusions about the drastically outlying features.

...