The copy number detection task is used to detect regions of DNA copy number imbalance within the genome for DNA-Seq experiments.   Partek^® Flow^® provides the CNVkit¹ methodology (https://cnvkit.readthedocs.io/en/stable/) to find regions of altered copy number, optimized for targeted resequencing of whole-exome and targeted panels that utilize a hybrid capture approach.  The methodology uses both targeted reads and nonspecific off-target reads divided into bins to determine copy number, subsequently normalizing the data to a pooled reference of control samples and correcting for systematic biases.

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