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• Linux: Ubuntu^® 12.04, Redhat^® 6, CentOS^® 6, or newer
• Mac: OS X Yosemite 10.10 or newer
• 64-bit 2GHz quad-core processor
• 32GB 48GB of onboard memory
• 48GB of swap space
• 1TB of storage available for data
• /opt – 100GB of storage available for installation

Note that some analyses have higher requirements, e.g. to run the STAR aligner on a reference genome of size ~3 GB (such as human, mouse or rat), 16 cores with 38 GB of RAM are required. Input sample file size can also impact memory usage, which is particularly the case for TopHat alignments.

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