PGS Documentation

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SubtitleTextSelecting Finding Overlapping Genes form the main toolbar
AnchorNameSelecting Finding Overlapping Genes

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  • Select Create a new spreadsheet with genes that overlap with the regions in the Find Overlapping Genes dialog
  • Select OK
  • Select an annotation - this tutorial uses RefSeq Transcripts - 2014-01-03 
  • You can select a name for the new list, we have named it gene-list
  • Select OK 

A new spreadsheet will be created as a child spreadsheet (Figure 2)

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SubtitleTextAnnotating the differentially methylated CpG loci with genes
AnchorNameOverlapping Genes List

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Partek Genomics Suite offers several tools to help interpret this list of genes. First, let's look at Gene Set Analysis

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SubtitleTextGO enrichment browser showing gene groups overrepresented in the list of genes which overlap with differentially methylated CpG loci
AnchorNameGO Enrichment spreadsheet

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Next, we can perform Pathway Analysis to see which pathways are over represented in the gene overlapped by differentially regulated CpG loci. 

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