The significant CpG loci detected in the previous step actually form a methylation signature that differentiates between LCLs and B cells. We can build and visualize this methylation signature using clustering and a heat map.
- Select the LCLs vs. B cells spreadsheet in the spreadsheet pane on the left
- Select Cluster Based on Significant Genes from the Visualization panel of the Illumina BeadArray Methylation workflow
- Select Hierarchical Clustering for Specify Method (Figure 1)
- Select OK
- Verify that LCLs vs B cells is selected in the drop-down menu
- Select Standardize for Expression normalization (Figure 2)
- Select OK
The heat map will be displayed on the Hierarchical Clustering tab (Figure 3).
Additional Assistance
If you need additional assistance, please visit our support page to submit a help ticket or find phone numbers for regional support.
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