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An important consideration when analyzing UMI data are the errors introduced into the UMIs themselves during PCR amplification of the original molecule. If these errors are not accounted for and each sequenced UMI is considered to be representative of the original UMI, the number of unique molecules can be significantly overestimated. To account for this, the Deduplicate UMIs task uses an implementation of the UMI-tools algorithm described in Smith et al. 2017. Paired-end read support was further improved by incorporating components of the UMI deduplication tool Connor.  

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