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Cluster 6 has several interesting biomarkers. The top biomarker is CXCL13, a gene expressed by follicular B helper T cells (Tfh cells). Two of the other biomarkers are Another biomarker is the PD-1 protein, which is expressed in Tfh cells. This protein promotes self-tolerance and is a target for immunotherapy drugs. The TIGIT protein is also expressed in cluster 8 6 and is another immunotherapy drug target that promotes self-tolerance.

Cluster 4 expresses several marker genes associated with cytotoxicity (e.g. NKG7 and GZMA) and the both CD3 and CD8 proteinproteins. Thus, these are likely to be cytotoxic cells. 

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