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This method is similar to the default method in the Drop-seq cookbook, which collapses UMI barcodes with a hamming distance of 1. 

This method will may output more UMIs than the default behavior as only UMIs within an edit distance of 1 are summarized, whereas UMIs with a greater distance can be linked in the UMI-tools method. For a comparison of the two approaches, please see the Adjacency (CellRanger) and Directional (UMI-tools) methods described in Smith et al. 2017. 

 

 

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